3-Amino-4-(1H-pyrrol-1-yl)benzenol

Base Information

• Chemical Name: 3-Amino-4-(1H-pyrrol-1-yl)benzenol
• CAS No.: 1228182-66-8
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.202
• Mol file: 1228182-66-8.mol

Synonyms:

Chemical Property of 3-Amino-4-(1H-pyrrol-1-yl)benzenol

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-4-(1H-pyrrol-1-yl)benzenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Amino-4-(1H-pyrrol-1-yl)benzenol

There total 2 articles about 3-Amino-4-(1H-pyrrol-1-yl)benzenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

1-(4-hydroxy-2-nitrophenyl)-1H-pyrrole (251649-40-8) → 3-amino-4-(1H-pyrrol-1-yl)phenol (1228182-66-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 5h;

DOI:10.1021/acs.jmedchem.5b01762

Reference yield:

4-hydroxy-2-nitroaniline (610-81-1) → 3-amino-4-(1H-pyrrol-1-yl)phenol (1228182-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 3 h / Reflux

2: hydrogen; palladium 10% on activated carbon / methanol / 5 h

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol;

DOI:10.1021/acs.jmedchem.5b01762

Reference yield:

3-amino-4-(1H-pyrrol-1-yl)phenol (1228182-66-8) → 4-(4-aminophenyl)pyrrolo[1,2-a]quinoxalin-7-ol trifluoroacetic acid salt

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2,3-Benzotriazole; aluminum (III) chloride / tetrahydrofuran / 20 °C

1.2: 24 h / 55 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 5 h

With 1,2,3-Benzotriazole; aluminum (III) chloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.5b01762

upstream raw materials:

1-(4-hydroxy-2-nitrophenyl)-1H-pyrrole

4-hydroxy-2-nitroaniline