sappanone A

Base Information

Chemical Name:sappanone A
CAS No.:102067-84-5
Molecular Formula:C₁₆H₁₂O₅
Molecular Weight:284.268
Hs Code.:
Mol file:102067-84-5.mol

Synonyms:

Suppliers and Price of sappanone A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SappanoneA
50mg
$ 910.00

DC Chemicals
SappanoneA
003
$ 1900.00

DC Chemicals
SappanoneA
002
$ 950.00

DC Chemicals
SappanoneA >98%
100 mg
$ 550.00

Cayman Chemical
SappanoneA ≥98%
50 mg
$ 792.00

Arctom
SappanoneA ≥98%
5mg
$ 468.00

Total 12 raw suppliers

Chemical Property of sappanone A

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

SappanoneA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.
Uses Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.

Technology Process of sappanone A

There total 2 articles about sappanone A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 76240-27-2
7-hydroxy-2,3-dihydro-4H-chromen-4-one

: 139-85-5
3,4-dihydroxybenzaldehyde

: 112458-02-3,102067-84-5
sappanone A

Guidance literature:: With pyrrolidine; In ethanol; at 89 ℃; for 12h; Inert atmosphere;

Reference yield:

: 108-46-3
recorcinol

: 112458-02-3,102067-84-5
sappanone A

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / 3 h / 80 °C

2: sodium hydroxide / water / 1 h / 0 °C

3: pyrrolidine / ethanol / 12 h / 89 °C / Inert atmosphere

With pyrrolidine; trifluorormethanesulfonic acid; sodium hydroxide; In ethanol; water;