Technology Process of C10H12Br2O
There total 3 articles about C10H12Br2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trans-3-(3-methylphenyl)-2-propen-1-ol;
With
BrTi(OiPr)3; diethyl dibromomalonate;
In
nitromethane; toluene;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
diethyl dibromomalonate;
In
nitromethane; toluene;
for 16h;
Overall yield = 79 %Spectr.; enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja4083182
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.75 h / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere
3.1: BrTi(OiPr)3; diethyl dibromomalonate / toluene; nitromethane / 0.25 h / 20 °C / Inert atmosphere
3.2: 16 h / Inert atmosphere
With
BrTi(OiPr)3; diethyl dibromomalonate; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; nitromethane; toluene;
DOI:10.1021/ja4083182
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere
2.1: BrTi(OiPr)3; diethyl dibromomalonate / toluene; nitromethane / 0.25 h / 20 °C / Inert atmosphere
2.2: 16 h / Inert atmosphere
With
BrTi(OiPr)3; diethyl dibromomalonate; diisobutylaluminium hydride;
In
nitromethane; toluene;
DOI:10.1021/ja4083182
