(2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate

Base Information

Chemical Name:(2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate
CAS No.:111138-55-7
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:
DSSTox Substance ID:DTXSID901164925
Nikkaji Number:J2.203.025F

Synonyms:(2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate;111138-55-7;DTXSID901164925;2,5-Dimethyl (2R,5R)-1-(phenylmethyl)-2,5-pyrrolidinedicarboxylate

Suppliers and Price of (2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:277.13140809
Heavy Atom Count:20
Complexity:328

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CCC(N1CC2=CC=CC=C2)C(=O)OC
Isomeric SMILES:COC(=O)[C@H]1CC[C@@H](N1CC2=CC=CC=C2)C(=O)OC

Technology Process of (2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate

There total 21 articles about (2R,5R)-Dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 102508-03-2
cis-2,5-dimethyl N-benzylpyrrolidine-2,5-dicarboxylate

: 116836-61-4,51483-87-5,102508-03-2,111138-55-7,118396-01-3,134356-90-4
trans-1-Benzyl-2,5-pyrrolidindicarbonsaeure-dimethylester

Guidance literature:: With sodium methylate; In methanol; Heating;
DOI:10.1016/S0040-4039(00)73281-3

Reference yield: 49.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: (+/-)-trans-1-benzylpyrrolidine-2,5-dicarboxamide

: 1372722-14-9
(2R,5R)-methyl 1-benzyl-5-carbamoylpyrrolidine-2-carboxylate

: 111138-55-7
(2R,5R)-dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate

: (2S,5S)-1-benzylpyrrolidine-2,5-dicarboxamide

Guidance literature:: (+/-)-trans-1-benzylpyrrolidine-2,5-dicarboxamide; With Rhodococcus erythropolis AJ₂₇₀ cells; In dimethyl sulfoxide; at 30 ℃; for 15h; pH=7; aq. phosphate buffer; Resolution of racemate; Enzymatic reaction;

diazomethane; In methanol; diethyl ether; optical yield given as %ee; enantioselective reaction; Cooling with ice;
DOI:10.1021/jo300412j