C₂₈H₂₂F₃N₅O₂

Base Information

• Chemical Name: C₂₈H₂₂F₃N₅O₂
• CAS No.: 1033768-70-5
• Molecular Formula: C₂₈H₂₂F₃N₅O₂
• Molecular Weight: 517.51
• Mol file: 1033768-70-5.mol

Synonyms:

Chemical Property of C₂₈H₂₂F₃N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₂F₃N₅O₂

There total 7 articles about C₂₈H₂₂F₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) + C23H19F3N4O2 (1369966-07-3) → C28H22F3N5O2 (1033768-70-5)

Guidance literature:

With piperidine; In ethanol; at 80 ℃; for 2h;

DOI:10.1021/ml200261d

Reference yield:

dimethyl 2-(4-bromo-2-nitrophenyl)malonate → C28H22F3N5O2 (1033768-70-5)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrogenchloride / water; acetic acid / 110 °C

2: sulfuric acid / 80 °C

3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 110 °C

4: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

5: triethylamine / tetrahydrofuran / 20 °C

6: piperidine / ethanol / 2 h / 80 °C

With piperidine; hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetic acid;

DOI:10.1021/ml200261d

Reference yield:

ethyl 2-(4-bromo-2-nitrophenyl)acetate (199328-35-3) → C28H22F3N5O2 (1033768-70-5)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 110 °C

2: palladium 10% on activated carbon; hydrogen / acetic acid / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

4: piperidine / ethanol / 2 h / 80 °C

With piperidine; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid;

DOI:10.1021/ml200261d

upstream raw materials:

2-pyrrole aldehyde

C₂₃H₁₉F₃N₄O₂

ethyl 2-(4-bromo-2-nitrophenyl)acetate

6-((5-amino-2-methylphenyl)amino)indolin-2-one