5-(trifluoromethyl)nicotinoyl chloride

Base Information

• Chemical Name: 5-(trifluoromethyl)nicotinoyl chloride
• CAS No.: 1092506-65-4
• Molecular Formula: C₇H₃ClF₃NO
• Molecular Weight: 209.555
• Mol file: 1092506-65-4.mol

Synonyms:

Chemical Property of 5-(trifluoromethyl)nicotinoyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(trifluoromethyl)nicotinoyl chloride

There total 1 articles about 5-(trifluoromethyl)nicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(trifluoromethyl)pyridine-3-carboxylic acid (131747-40-5) → 5-(trifluoromethyl)nicotinoyl chloride (1092506-65-4)

Guidance literature:

With thionyl chloride; In chloroform; at 20 ℃; for 1.25h; Heating / reflux;

Reference yield: 74.0%

5-(trifluoromethyl)nicotinoyl chloride (1092506-65-4) + 3-benzothiazol-2-ylphenylamine (41230-21-1) → C20H12F3N3OS

Guidance literature:

With pyridine; In tetrahydrofuran; at -40 ℃; Inert atmosphere;

DOI:10.1021/acsinfecdis.0c00680

Reference yield: 68.0%

5-(trifluoromethyl)nicotinoyl chloride (1092506-65-4) + 4-(1H-benzimidazol-2-yl)aniline (2963-77-1) → N-(4-(1H-benzo[d]imidazole-2-yl)phenyl)-3-(trifluoromethyl)nicotinamide

Guidance literature:

With pyridine; at -40 ℃;

DOI:10.1016/j.ejmech.2018.09.060

upstream raw materials:

5-(trifluoromethyl)pyridine-3-carboxylic acid

Refernces

• 1、 Openshaw, Roxanne,Maepa, Keletso,Benjamin, Stefan J.,Wainwright, Lauren,Combrinck, Jill M.,Hunter, Roger,Egan, Timothy J.. "A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes". . p. 362 - 376. Retrieved 2021.
• 2、 Zhang, Chun-Hui,Chen, Kai,Jiao, Yan,Li, Lin-Li,Li, Ya-Ping,Zhang, Rong-Jie,Zheng, Ming-Wu,Zhong, Lei,Huang, Shen-Zhen,Song, Chun-Li,Lin, Wan-Ting,Yang, Jiao,Xiang, Rong,Peng, Bing,Han, Jun-Hong,Lu, Guang-Wen,Wei, Yu-Quan,Yang, Sheng-Yong. "From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer". supporting information. p. 9788 - 9805. Retrieved 2016/11/19.