(R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

Base Information

• Chemical Name: (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate
• CAS No.: 1198319-72-0
• Molecular Formula: C₂₅H₂₃N₅O₃
• Molecular Weight: 441.489
• Mol file: 1198319-72-0.mol

Synonyms:

Chemical Property of (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

There total 1 articles about (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoquinoline-5-carboxylic acid (27810-64-6) + (R)-6-(hydroxymethyl)-2-(2-phenylethyl)-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-one (1198319-68-4) → (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate (1198319-72-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2009.09.053

Reference yield: 45.0%

N-methyl-3-formylindole (19012-03-4) + (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate (1198319-72-0) → (R)-(4-((1-methyl-1H-indol-3-yl)methyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate (1198319-80-0)

Guidance literature:

N-methyl-3-formylindole; (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate; With acetic acid; In dichloromethane;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 5h;

DOI:10.1016/j.bmcl.2009.09.053

Reference yield: 30.0%

4-hydroxy-3-methyl-benzaldehyde (15174-69-3) + (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate (1198319-72-0) → (R)-(4-(4-hydroxy-3-methylbenzyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate (1198319-81-1)

Guidance literature:

4-hydroxy-3-methyl-benzaldehyde; (R)-(8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate; With acetic acid; In dichloromethane;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 5h;

DOI:10.1016/j.bmcl.2009.09.053

upstream raw materials:

isoquinoline-5-carboxylic acid

(R)-6-(hydroxymethyl)-2-(2-phenylethyl)-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-one

Downstream raw materials:

(R)-(4-((1-methyl-1H-indol-3-yl)methyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

(R)-(4-(4-hydroxy-3-methylbenzyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

(R)-(4-(3-methylbenzyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

(R)-(4-(4-bromobenzyl)-8-oxo-2-(2-phenethyl)-2,4,5,6,7,8-hexahydropyrazolo[4,3-e][1,4]diazepin-6-yl)methyl isoquinoline-5-carboxylate

Refernces