N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide
CAS No.:1363161-11-8
Molecular Formula:C₄₀H₄₀N₈O₄
Molecular Weight:696.809
Hs Code.:

N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

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Chemical Property of N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

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Technology Process of N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

There total 12 articles about N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₃₈N₈O₃

: 814-68-6,25189-84-8
acryloyl chloride

: 1363161-11-8
N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm201591k

Reference yield:

: C₃₀H₃₃N₅O₃S

: 1363161-11-8
N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

3: trifluoroacetic acid / iso-butanol / 18 h / 110 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; iso-butanol;
DOI:10.1021/jm201591k

Reference yield:

: 1363161-15-2
tert-butyl 3-(5-(hydroxymethyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1363161-11-8
N-(3-(3-(4-(benzyloxy)phenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 8 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: sodium acetate / methanol / 1 h / 20 °C

3: sodium tetrahydroborate / methanol / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6: trifluoroacetic acid / iso-butanol / 18 h / 110 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium acetate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; iso-butanol;
DOI:10.1021/jm201591k