N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide

Base Information

• Chemical Name: N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide
• CAS No.: 96042-08-9
• Molecular Formula: C₃₁H₃₀Br₆N₄O₁₁
• Molecular Weight: 1114.02
• Mol file: 96042-08-9.mol

Synonyms:

Chemical Property of N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide

There total 2 articles about N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetoxy-1-{4-[1-acetoxy-2-(10-acetoxy-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carbonylamino)-ethyl]-2,6-dibromo-phenoxy}-3-(10-acetoxy-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carbonylamino)-propane (73622-26-1,87099-86-3) → N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide (96042-08-9)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1016/S0040-4039(00)88087-9

Reference yield:

11-epi-fistularin-3 (73622-22-7,87099-50-1,150133-31-6) → N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide (96042-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Heating

2: KOH / methanol

With pyridine; potassium hydroxide; In methanol;

DOI:10.1016/S0040-4039(00)88087-9

Reference yield:

acetic anhydride (108-24-7) + N-{3-[2,6-Dibromo-4-(2-{3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionylamino}-1-hydroxy-ethyl)-phenoxy]-2-hydroxy-propyl}-3-(3,5-dibromo-2-hydroxy-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-propionamide (96042-08-9) → C43H42Br6N4O17

Guidance literature:

With pyridine; Heating;

DOI:10.1016/S0040-4039(00)88087-9

upstream raw materials:

2-acetoxy-1-{4-[1-acetoxy-2-(10-acetoxy-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carbonylamino)-ethyl]-2,6-dibromo-phenoxy}-3-(10-acetoxy-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carbonylamino)-propane

11-epi-fistularin-3