2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester

Base Information

• Chemical Name: 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester
• CAS No.: 877461-31-9
• Molecular Formula: C₃₃H₃₂N₄O₆
• Molecular Weight: 580.64
• Mol file: 877461-31-9.mol

Synonyms:

Chemical Property of 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester

There total 6 articles about 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetic acid benzyl ester (857636-44-3) → 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester (877461-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂; acetic acid / Pd/C / 8 h / 20 °C

2: 19 mg / TBTU; HOBt / dimethylformamide / 8 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1039/b514921e

Reference yield:

(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetic acid benzyl ester (380637-97-8) → 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester (877461-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 21 percent / acetonitrile / 4 h / Irradiation

2: H₂; acetic acid / Pd/C / 8 h / 20 °C

3: 19 mg / TBTU; HOBt / dimethylformamide / 8 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; 1: Paterno-Buchi reaction;

DOI:10.1039/b514921e

Reference yield:

thymidyl acetic acid (20924-05-4) → 2-[2-(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetylamino]-3-(1-methyl-1H-indol-3-yl)-propionic acid methyl ester (877461-31-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / p-TsOH / benzene / 15 h / Heating

2: 21 percent / acetonitrile / 4 h / Irradiation

3: H₂; acetic acid / Pd/C / 8 h / 20 °C

4: 19 mg / TBTU; HOBt / dimethylformamide / 8 h / 20 °C

With hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; acetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; benzene; 2: Paterno-Buchi reaction;

DOI:10.1039/b514921e

upstream raw materials:

(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetic acid

methyl (S)-2-amino-3-[1-methyl-1H-indol-3-yl]propanoate

(6-methyl-3,5-dioxo-8,8-diphenyl-7-oxa-2,4-diaza-bicyclo[4.2.0]oct-2-yl)-acetic acid benzyl ester

thymidyl acetic acid