(2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Base Information

• Chemical Name: (2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine
• CAS No.: 1000062-33-8
• Molecular Formula: C₃₉H₄₅N₃O₅S
• Molecular Weight: 667.869
• Mol file: 1000062-33-8.mol

Synonyms:

Chemical Property of (2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

There total 1 articles about (2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S)-2-Chlorocarbonyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester + (7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan (152513-88-7) → (2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (1000062-33-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/ardp.200700060

Reference yield:

(2S,4S)-2-[7-(t-butyloxycarbonylamino-5-azaspiro[2.4]heptane)carbonyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (1000062-33-8) → C34H37N3O3S

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1002/ardp.200700060

upstream raw materials:

(7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan