Technology Process of C19H14F4N4
There total 14 articles about C19H14F4N4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 2h;
DOI:10.1016/j.bmcl.2014.05.082
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C
2: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 - 20 °C
3: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C
With
diethylamino-sulfur trifluoride; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.05.082
- Guidance literature:
-
Multi-step reaction with 2 steps
1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 0 - 20 °C
2: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C
With
diethylamino-sulfur trifluoride; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1016/j.bmcl.2014.05.082