2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide

Base Information

• Chemical Name: 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide
• CAS No.: 1292259-33-6
• Molecular Formula: C₂₇H₂₃F₄N₃O₆S
• Molecular Weight: 593.556
• Mol file: 1292259-33-6.mol

Synonyms:

Chemical Property of 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide

There total 6 articles about 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-trifluoromethylbenzenesulfonyl chloride (776-04-5) + 2-[4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yloxy]-N,N-dimethylacetamide → 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide (1292259-33-6)

Guidance literature:

With pyridine; at 60 ℃; for 72h;

DOI:10.1021/acs.jmedchem.8b00672

Reference yield: 33.0%

→ 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide (1292259-33-6)

Guidance literature:

Reference yield:

6-(benzyloxy)-4-chloro-7-methoxyquinoline (516526-43-5) → 2-{4-[2-fluoro-4-(2-trifluoromethylbenzenesulfonylamino)phenoxy]-6-methoxyquinolin-7-yloxy}-N,N-dimethylacetamide (1292259-33-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / chlorobenzene / 48 h / Reflux

2.1: hydrogen bromide; acetic acid / 2 h / 20 °C

2.2: 24 h

3.1: potassium carbonate / diphenylether / 5 h / 160 °C

4.1: ammonium chloride; zinc / ethanol; water / 3 h / Reflux

5.1: pyridine / 72 h / 60 °C

With pyridine; hydrogen bromide; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In diphenylether; ethanol; water; chlorobenzene;

DOI:10.1021/acs.jmedchem.8b00672

upstream raw materials:

2-trifluoromethylbenzenesulfonyl chloride

6-(benzyloxy)-4-chloro-7-methoxyquinoline

6-benzyloxy-4-(2-fluoro-4-nitrophenoxy)-7-methoxyquinoline

4-(2-fluoro-4-nitrophenoxy)-7-methoxylquinolyl-6-ol