5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester

Base Information

• Chemical Name: 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester
• CAS No.: 753029-55-9
• Molecular Formula: C₅₄H₆₆N₆O₁₃
• Molecular Weight: 1007.15

Synonyms:

Chemical Property of 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester

There total 6 articles about 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl 5-aminoisophthalate (99-27-4) → 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester (753029-55-9)

Guidance literature:

Multi-step reaction with 7 steps

1: EDC*HCl; HOBt*H₂O / dimethylformamide

2: aq. HCl / dioxane

3: EDC*HCl; HOBt*H₂O / dimethylformamide

4: aq. HCl / dioxane

5: EDC*HCl; HOBt*H₂O / dimethylformamide

6: aq. HCl / dioxane

7: EDC*HCl; HOBt*H₂O / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.12.088

Reference yield:

(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyric acid (105181-72-4) → 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester (753029-55-9)

Guidance literature:

Multi-step reaction with 7 steps

1: EDC*HCl; HOBt*H₂O / dimethylformamide

2: aq. HCl / dioxane

3: EDC*HCl; HOBt*H₂O / dimethylformamide

4: aq. HCl / dioxane

5: EDC*HCl; HOBt*H₂O / dimethylformamide

6: aq. HCl / dioxane

7: EDC*HCl; HOBt*H₂O / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.12.088

Reference yield:

5-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-isophthalic acid dimethyl ester → 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester (753029-55-9)

Guidance literature:

Multi-step reaction with 5 steps

1: EDC*HCl; HOBt*H₂O / dimethylformamide

2: aq. HCl / dioxane

3: EDC*HCl; HOBt*H₂O / dimethylformamide

4: aq. HCl / dioxane

5: EDC*HCl; HOBt*H₂O / dimethylformamide

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.12.088

upstream raw materials:

Boc-Dap(Fmoc)-OH

dimethyl 5-aminoisophthalate

(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyric acid

5-{(2R,3S)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-2-hydroxy-4-phenyl-butyrylamino}-isophthalic acid dimethyl ester

Downstream raw materials:

5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(ethoxyoxalyl-amino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 753029-55-9 5-[(2R,3S)-3-((S)-2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-methyl-butyrylamino}-4-methyl-pentanoylamino)-2-hydroxy-4-phenyl-butyrylamino]-isophthalic acid dimethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send