Ac-Ser-Leu-Asn--Ile-Val-OMe

Base Information

• Chemical Name: Ac-Ser-Leu-Asn--Ile-Val-OMe
• CAS No.: 127231-48-5
• Molecular Formula: C₃₉H₇₀N₈O₁₁
• Molecular Weight: 827.032

Synonyms:

Chemical Property of Ac-Ser-Leu-Asn--Ile-Val-OMe

Chemical Property:

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Technology Process of Ac-Ser-Leu-Asn--Ile-Val-OMe

There total 11 articles about Ac-Ser-Leu-Asn--Ile-Val-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C46H76N8O11 (137150-30-2) → Ac-Ser-Leu-Asn--Ile-Val-OMe (127231-48-5,127306-19-8,137328-42-8)

Guidance literature:

With hydrogen; palladium dihydroxide; In acetic acid;

DOI:10.1021/jm00167a003

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → Ac-Ser-Leu-Asn--Ile-Val-OMe (127231-48-5,127306-19-8,137328-42-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) N-methylmorpholine, 2.) EDCl, HOBt

2: 4 N HCl / dioxane

3: 1.) N-methylmorpholine, 2.) EDCl, HOBt

4: 4 N HCl / dioxane

5: N-methylmorpholine

6: NaI, NaHCO₃ / dimethylformamide

7: NaBH₄ / methanol

8: H₂ / Pd(OH)2/C / acetic acid

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; palladium dihydroxide; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a003

Reference yield:

(S)-2-Amino-N1-[(S)-1-(2-chloro-acetyl)-3-methyl-butyl]-succinamide → Ac-Ser-Leu-Asn--Ile-Val-OMe (127231-48-5,127306-19-8,137328-42-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) N-methylmorpholine, 2.) EDCl, HOBt

2: 4 N HCl / dioxane

3: 1.) N-methylmorpholine, 2.) EDCl, HOBt

4: 4 N HCl / dioxane

5: N-methylmorpholine

6: NaI, NaHCO₃ / dimethylformamide

7: NaBH₄ / methanol

8: H₂ / Pd(OH)2/C / acetic acid

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; palladium dihydroxide; In 1,4-dioxane; methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a003

upstream raw materials:

C₄₆H₇₆N₈O₁₁

N-tert-butoxycarbonyl-L-leucine

Leu-chloromethyl ketone hydrochloride

{(S)-2-Carbamoyl-1-[(S)-1-(2-chloro-acetyl)-3-methyl-butylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

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