5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine

Base Information

• Chemical Name: 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine
• CAS No.: 132776-85-3
• Molecular Formula: C₅₄H₆₇F₆N₈O₁₂P
• Molecular Weight: 1165.14

Synonyms:

Chemical Property of 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine

Chemical Property:

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Technology Process of 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine

There total 2 articles about 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα,Nε-bis(trifluoroacetyl)-L-lysine (329-53-3) → 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine (132776-85-3,132776-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / dicyclohexylcarbodiimide / 12 h / Ambient temperature

2: 68 percent / CH₂Cl₂; acetonitrile / 16 h / Ambient temperature

3: 1. diisopropylethylamine / 1. acetonitrile, RT, 20 min, 2. 30 min

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;

DOI:10.1021/jo00009a044

Reference yield:

Nα,Nε-bis(trifluoroacetyl)-L-Lys-O-p-nitrophenyl ester (132776-83-1) → 5'-O--5-<3-oxo-3-<<2-<<1-oxo-2,6-bis<(trifluoroacetyl)amino>hexyl>amino>-ethyl>amino>propyl>-2'-deoxyuridine 3'-O-(N,N-diisopropylamino)(β-cyanoethoxy)phosphine (132776-85-3,132776-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / CH₂Cl₂; acetonitrile / 16 h / Ambient temperature

2: 1. diisopropylethylamine / 1. acetonitrile, RT, 20 min, 2. 30 min

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1021/jo00009a044

upstream raw materials:

N^α,N^ε-bis(trifluoroacetyl)-L-lysine

Nα,Nε-bis(trifluoroacetyl)-L-Lys-O-p-nitrophenyl ester

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