Methyl (6R,7R,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate

Base Information

• Chemical Name: Methyl (6R,7R,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate
• CAS No.: 104855-37-0
• Molecular Formula: C₂₁H₂₅NO₆
• Molecular Weight: 387.433
• Mol file: 104855-37-0.mol

Synonyms:

Chemical Property of Methyl (6R,7R,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (6R,7R,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate

There total 40 articles about Methyl (6R,7R,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dienal (104840-65-5) → Methyl (6R,7S,2'R)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate (104855-37-0,104973-53-7,104973-54-8,104974-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride

2: m-chloroperbenzoic acid

3: tetrabutylammonium fluoride

4: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

With tetrabutyl ammonium fluoride; sodium hydride; 4-pyrrolidin-1-ylpyridine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1248/cpb.34.2668

Reference yield:

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dienal (104840-65-5) → Methyl (6R,7S,2'S)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate (104855-37-0,104973-53-7,104973-54-8,104974-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride

2: m-chloroperbenzoic acid

3: tetrabutylammonium fluoride

4: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

With tetrabutyl ammonium fluoride; sodium hydride; 4-pyrrolidin-1-ylpyridine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1248/cpb.34.2668

Reference yield:

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dienal (104840-65-5) → Methyl (6R,7R,2'R)-4-(N-Acetylphenylalanyloxy)-7,8-epoxy-7-methylocta-2(E),4(E)-dienoate (104855-37-0,104973-53-7,104973-54-8,104974-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride

2: m-chloroperbenzoic acid

3: tetrabutylammonium fluoride

4: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

With tetrabutyl ammonium fluoride; sodium hydride; 4-pyrrolidin-1-ylpyridine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1248/cpb.34.2668

upstream raw materials:

(S)-2-acetylamino-3-phenylpropanoic acid

Methyl 6(R)-Hydroxy-7,8-epoxy-7(S)-methylocta-2(E),4(E)-dienoate

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dienal

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dien-1-ol