1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Base Information

Chemical Name:1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS No.:1566577-89-6
Molecular Formula:C₃₆H₃₄F₄N₆O₆
Molecular Weight:722.696
Hs Code.:

1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Synonyms:

Suppliers and Price of 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 12 articles about 1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1566577-89-6
1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 9 steps

1: acetone / 12.5 h / 0 - 20 °C

2: nitric acid / dichloromethane / 4 h / 0 °C

3: toluene / 10 h / 110 °C

4: iron; acetic acid / 2.5 h / 20 - 80 °C

5: acetonitrile / 10 h / 85 °C

6: trichlorophosphate / 6 h / 85 °C

7: chlorobenzene / 30 h / 140 °C

8: iron; ammonium chloride / ethanol; water / 5 h / Reflux

9: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.01.014

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 1566577-89-6
1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 4 h / 0 °C

2: toluene / 10 h / 110 °C

3: iron; acetic acid / 2.5 h / 20 - 80 °C

4: acetonitrile / 10 h / 85 °C

5: trichlorophosphate / 6 h / 85 °C

6: chlorobenzene / 30 h / 140 °C

7: iron; ammonium chloride / ethanol; water / 5 h / Reflux

8: acetic acid / 80 °C

With nitric acid; iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.01.014

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1566577-89-6
1-(2-trifluoromethylphenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 10 h / 110 °C

2: iron; acetic acid / 2.5 h / 20 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

6: iron; ammonium chloride / ethanol; water / 5 h / Reflux

7: acetic acid / 80 °C

With iron; ammonium chloride; acetic acid; trichlorophosphate; In ethanol; water; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2014.01.014