-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Base Information

Chemical Name:-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid
CAS No.:148494-40-0
Molecular Formula:C₁₉H₁₇NO₆
Molecular Weight:355.347
Hs Code.:

<S-(E)>-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Synonyms:

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Chemical Property of -4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Chemical Property:

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Technology Process of -4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

There total 3 articles about -4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-<3-benzyloxy-2-<(benzyloxycarbonyl)amino>-3-oxopropyl>triphenylphosphonium chloride

: 148494-40-0
-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / H₂ / 10 percent Pd/C / ethanol / 4 h / 760 Torr / Ambient temperature

2: 1.) n-butyllithium, HMPA / 1.) THF, hexane, -70 deg C, 20 min, 2.) THF, hexane, -70 deg C, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1248/cpb.41.252

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 148494-40-0
-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bicarbonate / H₂O; dioxane / 1.5 h / 0 °C

2: 1.) n-butyllithium, HMPA / 1.) THF, hexane, -70 deg C, 20 min, 2.) THF, hexane, -70 deg C, 1 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1248/cpb.41.252

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 148494-36-4
(R)-2-<(benzyloxycarbonyl)amino>-3-(triphenylphosphonio)propanoate

: 148494-40-0
-4-(1,3-benzodioxol-5-yl)-2-<(benzyloxycarbonyl)amino>-3-butenoic acid

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -70 deg C, 20 min, 2.) THF, hexane, -70 deg C, 1 h;
DOI:10.1248/cpb.41.252