2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin

Base Information

• Chemical Name: 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin
• CAS No.: 1790-30-3
• Molecular Formula: C₂₃H₂₀O₈
• Molecular Weight: 424.407
• Mol file: 1790-30-3.mol

Synonyms:

Chemical Property of 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin

There total 7 articles about 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin (1790-30-3)

Guidance literature:

Multi-step reaction with 6 steps

1: AlCl₃ / CS₂

2: (i) H₂, aq. HClO₄, Pd-C, AcOH, (ii) polyphosphoric acid

3: p-cymene / Pd-C / Heating

4: Pb(OAc)4 / acetic acid; CHCl₃

5: (i) NaH, THF, (ii) /BRN= 2657296/

6: (i) AlCl₃, PhNO₂, (ii) aq. HCl

With lead(IV) acetate; aluminium trichloride; 4-methylisopropylbenzene; palladium on activated charcoal; In carbon disulfide; chloroform; acetic acid;

DOI:10.1002/hlca.19650480312

Reference yield:

2-methyl-4-oxo-4-(2,4,5-trimethoxy-phenyl)-butyric acid (1702-68-7) → 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin (1790-30-3)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) H₂, aq. HClO₄, Pd-C, AcOH, (ii) polyphosphoric acid

2: p-cymene / Pd-C / Heating

3: Pb(OAc)4 / acetic acid; CHCl₃

4: (i) NaH, THF, (ii) /BRN= 2657296/

5: (i) AlCl₃, PhNO₂, (ii) aq. HCl

With lead(IV) acetate; 4-methylisopropylbenzene; palladium on activated charcoal; In chloroform; acetic acid;

DOI:10.1002/hlca.19650480312

Reference yield:

5,7,8-trimethoxy-2-methyl-3,4-dihydro-2H-naphthalen-1-one (1702-71-2) → 2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-6-methoxy-naphthazarin (1790-30-3)

Guidance literature:

Multi-step reaction with 4 steps

1: p-cymene / Pd-C / Heating

2: Pb(OAc)4 / acetic acid; CHCl₃

3: (i) NaH, THF, (ii) /BRN= 2657296/

4: (i) AlCl₃, PhNO₂, (ii) aq. HCl

With lead(IV) acetate; 4-methylisopropylbenzene; palladium on activated charcoal; In chloroform; acetic acid;

DOI:10.1002/hlca.19650480312

upstream raw materials:

2-(1-Benzyloxycarbonyl-2-oxo-propyl)-3-methyl-5,6,8-trimethoxy-<1,4>naphthochinon

1,2,4-trimethoxy-benzene

benzyl acetoacetate

2-Methyl-5,7,8-trimethoxy-naphthol-⁽¹⁾