N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Base Information

Chemical Name:N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide
CAS No.:219537-86-7
Molecular Formula:C₄₀H₃₉N₃O₉
Molecular Weight:705.764
Hs Code.:

N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

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Chemical Property of N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

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Technology Process of N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

There total 9 articles about N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-{1-[(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-(tert-butyl-dimethyl-silanyloxy)-dihydro-furo[3,2-d][1,3]dioxin-4a-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

: 219537-86-7
N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; Yield given;
DOI:10.1016/S0960-894X(98)00566-6

Reference yield:

: 174848-29-4
1,3,4,6-tetra-O-benzoyl-D-fructofuranosyl acetate

: 219537-86-7
N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) BSA, 2.) SnCl₄ / 1.) MeCN, 70 deg C, 2.) from 0 deg C to RT

2: 49 percent / NaOMe / tetrahydrofuran

3: 90 percent / MeSO₃H / CH₂Cl₂

4: NaOMe / methanol

5: pyridine

6: 89 percent / imidazole

7: 1.) POCl₃, 1,2,4-triazole, Et₃N, 2.) conc. NH₄OH

8: pyridine

9: Bu₄NF, AcOH / tetrahydrofuran

With pyridine; 1H-imidazole; 1,2,4-Triazole; benzenesulfonamide; ammonium hydroxide; methanesulfonic acid; tetrabutyl ammonium fluoride; sodium methylate; tin(IV) chloride; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00566-6

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 219537-86-7
N-(1-{(4aS,6R,7R,7aS)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-dihydro-furo[3,2-d][1,3]dioxin-4a-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) BSA, 2.) SnCl₄ / 1.) MeCN, 70 deg C, 2.) from 0 deg C to RT

2: 49 percent / NaOMe / tetrahydrofuran

3: 90 percent / MeSO₃H / CH₂Cl₂

4: NaOMe / methanol

5: pyridine

6: 89 percent / imidazole

7: 1.) POCl₃, 1,2,4-triazole, Et₃N, 2.) conc. NH₄OH

8: pyridine

9: Bu₄NF, AcOH / tetrahydrofuran

With pyridine; 1H-imidazole; 1,2,4-Triazole; benzenesulfonamide; ammonium hydroxide; methanesulfonic acid; tetrabutyl ammonium fluoride; sodium methylate; tin(IV) chloride; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00566-6