(2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate

Base Information

• Chemical Name: (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate
• CAS No.: 674777-40-3
• Molecular Formula: C₂₃H₂₉NO₅S₂
• Molecular Weight: 463.619

Synonyms:

Chemical Property of (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate

There total 7 articles about (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + 2,2-Dimethyl-propionic acid (E)-(R)-4-amino-5-((R)-benzenesulfinyl)-pent-2-enyl ester; compound with trifluoro-acetic acid → (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(RS)-phenylsulfinyl]-2-pentenyl pivalate (674777-40-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2003.11.036

Reference yield:

(E)-3-<(4R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl>-2-propen-1-ol (123751-18-8) → (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(RS)-phenylsulfinyl]-2-pentenyl pivalate (674777-40-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 70 percent / methanol; camphor-10-sulfonic acid / 16 h / 20 °C

3: 63 percent / PBu₃ / tetrahydrofuran / 36 h / 72 °C

4: 45 percent / NaIO₄ / methanol; H₂O / 16.5 h / 0 - 20 °C

5: CH₂Cl₂ / 0.5 h / 0 °C

6: triethylamine / CH₂Cl₂ / 0 - 20 °C

With methanol; sodium periodate; tributylphosphine; camphor-10-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.tetasy.2003.11.036

Reference yield:

(4R)-4-(2-ethoxycarbonyl-vinyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (131713-27-4,134525-18-1,144070-31-5,149406-02-0) → (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(RS)-phenylsulfinyl]-2-pentenyl pivalate (674777-40-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 73 percent / diisobutylaluminium hydride; n-BuLi / toluene; hexane / 1.33 h / -78 - 20 °C

2: 83 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 70 percent / methanol; camphor-10-sulfonic acid / 16 h / 20 °C

4: 63 percent / PBu₃ / tetrahydrofuran / 36 h / 72 °C

5: 45 percent / NaIO₄ / methanol; H₂O / 16.5 h / 0 - 20 °C

6: CH₂Cl₂ / 0.5 h / 0 °C

7: triethylamine / CH₂Cl₂ / 0 - 20 °C

With methanol; sodium periodate; n-butyllithium; tributylphosphine; camphor-10-sulfonic acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;

DOI:10.1016/j.tetasy.2003.11.036

upstream raw materials:

p-toluenesulfonyl chloride

(E)-3-<(4R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl>-2-propen-1-ol

(4R)-4-(2-ethoxycarbonyl-vinyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

(2E,4R)-4-(tert-butyloxycarbonylamino)-5-hydroxy-2-pentenyl pivalate

Downstream raw materials:

N-[(1S,2R,3S)-2-bromo-4-(tert-butyldiphenylsilyloxy)-3-hydroxy-1-[(S_S)-phenylsulfinylmethyl]butyl]-4-methyl-1-benzenesulfonamide

N-[1-benzenesulfinylmethyl-4-(tert-butyl-diphenyl-silanyloxy)-but-2-enyl]-4-methyl-benzenesulfonamide

N-[(1R,2E)-4-hydroxy-1-[(R_S)-phenylsulfinylmethyl]-2-butenyl]-4-methyl-1-benzenesulfonamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 674777-40-3 (2E,4R)-4-(4-methylphenylsulfonamido)-5-[(R_S)-phenylsulfinyl]-2-pentenyl pivalate

Send

Send

Metric Ton KG G Pound L ML

Send

Send