Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester

Base Information

• Chemical Name: Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester
• CAS No.: 145794-03-2
• Molecular Formula: C₄₅H₅₁N₆O₁₄P₃
• Molecular Weight: 992.853
• Mol file: 145794-03-2.mol

Synonyms:

Chemical Property of Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester

There total 6 articles about Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2-cyanoethyl) diisopropylamidophosphite (102690-88-0) → Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester (145794-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrazole / CH₂Cl₂

2: 70percent t-BuOOH / H₂O

3: HgO, HgCl₂ / acetone; H₂O

4: tetrazole / CH₂Cl₂

With 1H-tetrazole; tert.-butylhydroperoxide; mercury dichloride; mercury(II) oxide; In dichloromethane; water; acetone;

DOI:10.1039/c39900001500

Reference yield:

1-O-allyl-2,3,6-tri-O-benzyl-myo-inositol (114218-16-5,114297-86-8,114419-07-7,145843-73-8) → Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester (145794-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1: tris(triphenylphosphine)rhodium(I) chloride, DABCO / ethanol; benzene; H₂O

2: tetrazole / CH₂Cl₂

3: 70percent t-BuOOH / H₂O

4: HgO, HgCl₂ / acetone; H₂O

5: tetrazole / CH₂Cl₂

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-tetrazole; tert.-butylhydroperoxide; Wilkinson's catalyst; mercury dichloride; mercury(II) oxide; In ethanol; dichloromethane; water; acetone; benzene;

DOI:10.1039/c39900001500

Reference yield:

(+/-)-2,3,6-tri-O-benzyl-1-O-(prop-1-enyl)-myo-inositol (131919-46-5,132016-06-9,145843-75-0,146611-43-0,146611-44-1) → Phosphoric acid bis-(2-cyano-ethyl) ester (1R,2S,3R,4R,5S,6R)-2,4,5-tris-benzyloxy-3-[bis-(2-cyano-ethoxy)-phosphanyloxy]-6-[bis-(2-cyano-ethoxy)-phosphoryloxy]-cyclohexyl ester (145794-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrazole / CH₂Cl₂

2: 70percent t-BuOOH / H₂O

3: HgO, HgCl₂ / acetone; H₂O

4: tetrazole / CH₂Cl₂

With 1H-tetrazole; tert.-butylhydroperoxide; mercury dichloride; mercury(II) oxide; In dichloromethane; water; acetone;

DOI:10.1039/c39900001500

upstream raw materials:

bis(2-cyanoethyl) diisopropylamidophosphite

(+/-)-1,2,4-tri-O-benzyl-5,6-bis-myo-inositol

1-O-allyl-2,3,6-tri-O-benzyl-myo-inositol

(+/-)-2,3,6-tri-O-benzyl-1-O-(prop-1-enyl)-myo-inositol

Downstream raw materials:

(+/-)-2,3,6-tri-O-benzyl-1-O--4,5-bis-myo-inositol