3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Base Information

Chemical Name:3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester
CAS No.:205442-05-3
Molecular Formula:C₃₉H₃₈N₂O₉
Molecular Weight:678.739
Hs Code.:

3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Synonyms:

Suppliers and Price of 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

There total 13 articles about 3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 205442-04-2
3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

: 205442-05-3
3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Guidance literature:: With pyridine; (HF)n;

Reference yield:

: 13866-57-4
(E)-methyl 4-hydroxy-3-methylbut-2-enoate

: 205442-05-3
3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: i-Pr₂NEt

2: aq. NaOH

3: 1-ethyl 3-(dimethylaminopropyl)carbodiimide hydrochloride, Et₃N

4: 92 percent / aq. NaOH

5: 100 percent / C₆H₁₁NCNCH₂N(Me)(CH₂CH₂OCH₂CH₂)⁽¹⁺⁾*TsO^(1-)

6: 58 percent / toluene / 60 °C

7: DDQ

8: NaBH₄

9: 59 percent / 1.) (DHQ)2PHAL, OsO₄; 2.) H₂S / CH₂Cl₂ / -15 °C

10: 81 percent / γ-collidine

11: 84 percent / DBU

12: 78 percent / 1-ethyl 3-(dimethylaminopropyl)carbodiimide hydrochloride, DMAP

13: 84 percent / (HF)n, pyridine

With pyridine; 2,4,6-trimethyl-pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; (HF)n; Hydroquinone 1,4-phthalazinediyl diether; C₆H₁₁NCNCH₂N(Me)(CH₂CH₂OCH₂CH₂)⁽¹⁺⁾*TsO^(1-); hydrogen sulfide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; toluene;

Reference yield:

: 205441-81-2
(E)-3-(benzyloxymethoxy)methyl-2-butenoic acid

: 205442-05-3
3-Methoxy-5-methyl-naphthalene-1-carboxylic acid (R)-{4-[(3R,4R,5S)-3,4-bis-benzyloxy-5-hydroxymethyl-pyrrolidin-(2E)-ylidene]-5-oxo-4,5-dihydro-oxazol-2-yl}-((S)-2-methyl-oxiranyl)-methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 1-ethyl 3-(dimethylaminopropyl)carbodiimide hydrochloride, Et₃N

2: 92 percent / aq. NaOH

3: 100 percent / C₆H₁₁NCNCH₂N(Me)(CH₂CH₂OCH₂CH₂)⁽¹⁺⁾*TsO^(1-)

4: 58 percent / toluene / 60 °C

5: DDQ

6: NaBH₄

7: 59 percent / 1.) (DHQ)2PHAL, OsO₄; 2.) H₂S / CH₂Cl₂ / -15 °C

8: 81 percent / γ-collidine

9: 84 percent / DBU

10: 78 percent / 1-ethyl 3-(dimethylaminopropyl)carbodiimide hydrochloride, DMAP

11: 84 percent / (HF)n, pyridine

With pyridine; 2,4,6-trimethyl-pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; (HF)n; Hydroquinone 1,4-phthalazinediyl diether; C₆H₁₁NCNCH₂N(Me)(CH₂CH₂OCH₂CH₂)⁽¹⁺⁾*TsO^(1-); hydrogen sulfide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; toluene;