(S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide

Base Information

• Chemical Name: (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide
• CAS No.: 1026446-76-3
• Molecular Formula: C₂₀H₂₈N₆O₆
• Molecular Weight: 448.479
• Mol file: 1026446-76-3.mol

Synonyms:

Chemical Property of (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide

There total 3 articles about (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (R)-2-amino-2-methyl-butyrate hydrochloride (118725-00-1) → (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide (1026446-76-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / DCC, HOBt

2: 88 percent / NaOH / methanol / 2 h / Ambient temperature

3: 1.) TFA, 2.) DCC, HOBt / 1.) room temperature, 30 min, 2.) CH₂Cl₂, room temperature, overnight

4: TFA / 0.33 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;

DOI:10.1039/P19950002115

Reference yield:

Boc-Gly-D-Iva-OMe (171416-03-8) → (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide (1026446-76-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / NaOH / methanol / 2 h / Ambient temperature

2: 1.) TFA, 2.) DCC, HOBt / 1.) room temperature, 30 min, 2.) CH₂Cl₂, room temperature, overnight

3: TFA / 0.33 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol;

DOI:10.1039/P19950002115

Reference yield:

Boc-Gly-D-Iva-OH (171416-04-9) → (S)-1-[(R)-2-(2-Amino-acetylamino)-2-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(4-nitro-phenylcarbamoyl)-methyl]-amide (1026446-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, 2.) DCC, HOBt / 1.) room temperature, 30 min, 2.) CH₂Cl₂, room temperature, overnight

2: TFA / 0.33 h / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1039/P19950002115

upstream raw materials:

methyl (R)-2-amino-2-methyl-butyrate hydrochloride

Boc-Gly-D-Iva-OMe

Boc-Gly-D-Iva-OH

Refernces