C₆₀H₈₂N₈O₁₂

Base Information

• Chemical Name: C₆₀H₈₂N₈O₁₂
• CAS No.: 324764-16-1
• Molecular Formula: C₆₀H₈₂N₈O₁₂
• Molecular Weight: 1107.36

Synonyms:

Chemical Property of C₆₀H₈₂N₈O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₈₂N₈O₁₂

There total 12 articles about C₆₀H₈₂N₈O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C60H82N8O12 (324764-16-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 92 percent / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide / 0.67 h

2.1: TFA / CHCl₃ / 0.33 h / 20 °C

3.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

3.2: 444 mg / DIPEA / dimethylformamide / 0.5 h

4.1: NaOH / dioxane; methanol; H₂O / 0.07 h

5.1: 330 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide / 0.67 h

6.1: NaOH / dioxane; methanol; H₂O

7.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

7.2: 120 mg / DIPEA / dimethylformamide / 0.5 h

8.1: NaOH / dioxane; methanol; H₂O

9.1: 83 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

10.1: NaOH / dioxane; methanol; H₂O

11.1: 41 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

With dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

L-Phenylalaninol (3182-95-4) → C60H82N8O12 (324764-16-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 92 percent / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide / 0.67 h

2.1: TFA / CHCl₃ / 0.33 h / 20 °C

3.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

3.2: 444 mg / DIPEA / dimethylformamide / 0.5 h

4.1: NaOH / dioxane; methanol; H₂O / 0.07 h

5.1: 330 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide / 0.67 h

6.1: NaOH / dioxane; methanol; H₂O

7.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

7.2: 120 mg / DIPEA / dimethylformamide / 0.5 h

8.1: NaOH / dioxane; methanol; H₂O

9.1: 83 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

10.1: NaOH / dioxane; methanol; H₂O

11.1: 41 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

With dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

(S)-tert-butyl 2-((S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate (169515-57-5) → C60H82N8O12 (324764-16-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: TFA / CHCl₃ / 0.33 h / 20 °C

2.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

2.2: 444 mg / DIPEA / dimethylformamide / 0.5 h

3.1: NaOH / dioxane; methanol; H₂O / 0.07 h

4.1: 330 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide / 0.67 h

5.1: NaOH / dioxane; methanol; H₂O

6.1: benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DMAP / dimethylformamide / 0.17 h

6.2: 120 mg / DIPEA / dimethylformamide / 0.5 h

7.1: NaOH / dioxane; methanol; H₂O

8.1: 83 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

9.1: NaOH / dioxane; methanol; H₂O

10.1: 41 mg / benzotriazol-1-yloxy-tris(Me₂N)phosphonium⁽¹⁺⁾*PF₆^(1-); DIPEA / dimethylformamide

With dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

(2S,4R)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

1-(tert-butoxycarbonyl)-L-proline

L-Phenylalaninol

(S)-tert-butyl 2-((S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)pyrrolidine-1-carboxylate

Downstream raw materials:

C₅₂H₆₆N₈O₁₂

2-[(4-hydroxy-pyrrolidine-2-carbonyl)-amino]-pentanedioic acid 5-amide 1-{[2-(4-hydroxy-2-{2-[2-(1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethyl]-amide}

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