2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Base Information

Chemical Name:2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester
CAS No.:96998-87-7
Molecular Formula:C₃₉H₄₀F₅N₇O₆S₂
Molecular Weight:861.914
Hs Code.:

2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

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Chemical Property of 2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

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Technology Process of 2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

There total 11 articles about 2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96965-18-3
Ethyl (R)-2-(1-aminoethyl)-thiazole-4-carboxylate

: 96998-87-7
2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / dipyridyl disulfide, Ph₃P

2: 1) diethyl azodicarboxylate, Ph₃P, HN₃, 2) H₂ / 2) Pd

3: 2) CF₃COOH

4: 89 percent

5: NaOH / H₂O

6: DCC / ethyl acetate

7: CF₃COOH

With sodium hydroxide; 2,2'-dipyridyldisulphide; tris-(2-chloro-ethyl)-amine; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium; In water; ethyl acetate;

Reference yield:

: 111946-67-9
2-((1S,2S)-1-Acetoxy-2-methyl-butyl)-thiazole-4-carboxylic acid ethyl ester

: 96998-87-7
2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) diethyl azodicarboxylate, Ph₃P, PhCOOH, 2) NaOH / 2) H₂O

2: 81 percent / dipyridyl disulfide, Ph₃P

3: 1) diethyl azodicarboxylate, Ph₃P, HN₃, 2) H₂ / 2) Pd

4: 2) CF₃COOH

5: 89 percent

6: NaOH / H₂O

7: DCC / ethyl acetate

8: CF₃COOH

With sodium hydroxide; 2,2'-dipyridyldisulphide; tris-(2-chloro-ethyl)-amine; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; benzoic acid; trifluoroacetic acid; diethylazodicarboxylate; palladium; In water; ethyl acetate;

Reference yield:

: 96965-16-1
2-[(1S)-1-(acetoxy)ethyl]thiazole-4-carboxylic acid ethyl ester

: 96998-87-7
2-[(R)-1-({2-[(1S,2S)-1-({(4S,5R)-2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-2-methyl-butyl]-thiazole-4-carbonyl}-amino)-ethyl]-thiazole-4-carboxylic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1) diethyl azodicarboxylate, Ph₃P, HN₃, 2) H₂ / 2) Pd

2: 81 percent / dipyridyl disulfide, Ph₃P

3: 1) diethyl azodicarboxylate, Ph₃P, HN₃, 2) H₂ / 2) Pd

4: 2) CF₃COOH

5: 89 percent

6: NaOH / H₂O

7: DCC / ethyl acetate

8: CF₃COOH

With sodium hydroxide; 2,2'-dipyridyldisulphide; tris-(2-chloro-ethyl)-amine; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium; In water; ethyl acetate;