<(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether

Base Information

• Chemical Name: <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether
• CAS No.: 124921-82-0
• Molecular Formula: C₂₇H₃₆N₂O₃SSi
• Molecular Weight: 496.746
• Mol file: 124921-82-0.mol

Synonyms:

Chemical Property of <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether

There total 2 articles about <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-(toluene-4-sulfonyl)-L-asparagine (36212-66-5) → <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether (124921-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / BH₃ / tetrahydrofuran; various solvent(s) / 44 h / Heating

2: Imidazol / dimethylformamide / 0.25 h / Ambient temperature

With 1H-imidazole; borane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

(2S)-4-amino-2-<<(4-methylphenyl)sulfonyl>amino>butan-1-ol (124921-81-9) + tert-butylchlorodiphenylsilane (58479-61-1) → <(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether (124921-82-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 0.25h; Ambient temperature;

Reference yield:

<(S)-4-Amino-2-<(4-methylphenyl)sulfonylamino>butyl>ether (124921-82-0) → (2S,8S)-2,8-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; hydrochloride

Guidance literature:

Multi-step reaction with 7 steps

1: 1) Carbonyldiimidazol / 1) CH₂Cl₂, ca. 45 min, room temperature, 2) 90 min

2: 33 percent / BH₃ / tetrahydrofuran / 1.33 h / Heating

4: e^-, Tetramethylammonium-chlorid / methanol / 4 h / 20 °C / ca. 10 V, 270 mA

6: Methyliodid / nitromethane; acetic acid / 2 h / 60 °C

7: Serdolit AS-6, Cl^--Form / methanol; acetonitrile

With Carbonyldiimidazole; Serdolit AS-6; borane; chloride; tetramethlyammonium chloride; methyl iodide; In tetrahydrofuran; methanol; nitromethane; acetic acid; acetonitrile;

upstream raw materials:

(2S)-4-amino-2-<<(4-methylphenyl)sulfonyl>amino>butan-1-ol

tert-butylchlorodiphenylsilane

N²-(toluene-4-sulfonyl)-L-asparagine

Downstream raw materials:

(2S,8S)-9-(tert-Butyldiphenylsilyloxy)-2,8-bis<(4-methylphenyl)sulfonylamino>-4-oxo-5-azanonansaeure-methylester

(2S,8S)-9-(tert-Butyldiphenylsilyloxy)-2,8-bis<(4-methylphenyl)sulfonylamino>-5-azanonanol

(2S,8S)-9-(tert-Butyldiphenylsilyloxy)-2,8-bis<(4-methylphenyl)sulfonylamino>-4-oxo-5-azanonanol

(2S,8S)-2,8-Bis(tert-butyldiphenylsilyloxymethyl)-3,4,6,7,8,9-hexahydro-9-<(4-methylphenyl)sulfonyl>-2H-pyrimido<1,2-a>pyrimidin