(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Base Information

Chemical Name:(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester
CAS No.:218943-39-6
Molecular Formula:C₄₆H₅₆Cl₃N₃O₁₂
Molecular Weight:949.323
Hs Code.:

(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

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Chemical Property of (S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

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Technology Process of (S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

There total 4 articles about (S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 218943-30-7
(3S)-3-tert-butoxycarbonylamino-5-benzyloxycarbonylpentanoic acid

: (S)-3-((S)-3-Amino-5-benzyloxycarbonyl-pentanoylamino)-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester; compound with trifluoro-acetic acid

: 218943-39-6
(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; 1.) 0 deg C, 30 min, 2.) r.t., 16 h;
DOI:10.1039/a805478i

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 218943-39-6
(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃ / tetrahydrofuran / 0.25 h / -25 °C

2: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

3: 71 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

4: 81 percent / Et₃N, HOBt, EDC / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) r.t., 16 h

With water; silver trifluoroacetate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/a805478i

Reference yield:

: 128135-31-9
4-tert-butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester

: 218943-39-6
(S)-3-[(S)-5-Benzyloxycarbonyl-3-((S)-5-benzyloxycarbonyl-3-tert-butoxycarbonylamino-pentanoylamino)-pentanoylamino]-hexanedioic acid 6-benzyl ester 1-(2,2,2-trichloro-ethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

2: 81 percent / Et₃N, HOBt, EDC / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) r.t., 16 h

With water; silver trifluoroacetate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/a805478i