(1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

Base Information

Chemical Name:(1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine
CAS No.:709658-79-7
Molecular Formula:C₃₀H₃₅NO₃
Molecular Weight:457.613
Hs Code.:

Synonyms:

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Chemical Property of (1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

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Technology Process of (1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

There total 5 articles about (1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 709658-78-6
(1'S,2R,3R,4S)-1',3,4-tris(phenylmethoxy)-2-pyrrolidinepentanol

: 709658-79-7
(1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

Guidance literature:: With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 0 - 4 ℃; for 20h;
DOI:10.1016/j.tet.2004.03.050

Reference yield:

: (2S,3R)-2-[4-(4-Methoxy-benzyloxy)-butyl]-3-vinyl-oxirane

: 709658-79-7
(1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

Guidance literature:: Multi-step reaction with 7 steps

1: LiOTf / acetonitrile / 1 h / 120 °C / microwave irradiation

2: diethyl ether / 18 h / 20 °C

3: benzylidene-bis-(tricyclohexylphosphine)dichlororuthenium / CH₂Cl₂ / 20 h / Heating

4: N-methylmorpholine N-oxide; K₂OsO₄ / acetone; H₂O / 20 h / 20 °C

5: NaH; nBu₄NF / tetrahydrofuran; various solvent(s) / 72 h / 20 °C

6: trifluoroacetic acid; anisole / CH₂Cl₂ / 2 h / 20 °C

7: CBr₄; triphenylphosphine; triethylamine / CH₂Cl₂ / 20 h / 0 - 4 °C

With potassium osmate(VI); carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; lithium trifluoromethanesulfonate; methoxybenzene; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; trifluoroacetic acid; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.tet.2004.03.050

Reference yield:

: 709658-73-1
(3S,4S)-8-[(4-methoxyphenyl)methoxy]-3-(2-propenylamino)-1-octen-4-ol

: 709658-79-7
(1R,2S,9S,9aR)-octahydro-1,2,9-tris(phenylmethoxy)-1H-pyrrolo[1,2-a]azepine

Guidance literature:: Multi-step reaction with 6 steps

1: diethyl ether / 18 h / 20 °C

2: benzylidene-bis-(tricyclohexylphosphine)dichlororuthenium / CH₂Cl₂ / 20 h / Heating

3: N-methylmorpholine N-oxide; K₂OsO₄ / acetone; H₂O / 20 h / 20 °C

4: NaH; nBu₄NF / tetrahydrofuran; various solvent(s) / 72 h / 20 °C

5: trifluoroacetic acid; anisole / CH₂Cl₂ / 2 h / 20 °C

6: CBr₄; triphenylphosphine; triethylamine / CH₂Cl₂ / 20 h / 0 - 4 °C

With potassium osmate(VI); carbon tetrabromide; tetrabutyl ammonium fluoride; sodium hydride; methoxybenzene; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; trifluoroacetic acid; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1016/j.tet.2004.03.050