4-Cyclohexyl-2-hydroxy-butyronitrile

Base Information

Chemical Name:4-Cyclohexyl-2-hydroxy-butyronitrile
CAS No.:104344-07-2
Molecular Formula:C₁₀H₁₇NO
Molecular Weight:167.251
Hs Code.:

Synonyms:

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Chemical Property of 4-Cyclohexyl-2-hydroxy-butyronitrile

Chemical Property:

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Technology Process of 4-Cyclohexyl-2-hydroxy-butyronitrile

There total 1 articles about 4-Cyclohexyl-2-hydroxy-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4361-28-8
3-cyclohexylpropanal

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 104344-07-2
4-Cyclohexyl-2-hydroxy-butyronitrile

Guidance literature:: With triethylamine; at 20 ℃;
DOI:10.1016/S0040-4020(99)00612-2

Reference yield:

: 104344-07-2
4-Cyclohexyl-2-hydroxy-butyronitrile

: 4-[2-cyclohexylethyl]-4,5-dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: CF₃COOH / 0 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.5 h / -60 °C

2.2: 64 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -60 °C

3.1: 64 percent / LiAlH(OEt)3 / diethyl ether

4.1: 96 percent / LiAlH₄ / diethyl ether / 0.25 h / 0 °C

5.1: 81 percent / p-toluenesulfonic acid monohydrate / methanol / 20 °C

6.1: 79 percent / Jones' reagent / acetone / 0.17 h / 0 °C

7.1: 39 percent / SOCl₂; pyridine / CH₂Cl₂ / 1 h / 0 °C

8.1: 100 percent / H₂ / Pd/C / ethyl acetate / 6 h / 20 °C / 3040 Torr

With pyridine; lithium aluminium tetrahydride; thionyl chloride; jones' reagent; hydrogen; toluene-4-sulfonic acid; lithium triethoxyaluminum hydride; trifluoroacetic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; ethyl acetate; acetone; 1.1: Addition / 2.1: Metallation / 2.2: Alkylation / 3.1: Reduction / 4.1: Reduction / 5.1: Cyclization / 6.1: Oxidation / 7.1: Dehydration / 8.1: Catalytic hydrogenation;
DOI:10.1016/S0040-4020(99)00612-2

Reference yield:

: 104344-07-2
4-Cyclohexyl-2-hydroxy-butyronitrile

: 249766-59-4
4-(2-cyclohexylethyl)-2-methoxy-5,5-dimethyl-tetrahydrofuran-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: CF₃COOH / 0 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.5 h / -60 °C

2.2: 64 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 2 h / -60 °C

3.1: 2.26 g / diethyl ether / 1.5 h / 0 °C

4.1: aq. NH₄Cl / tetrahydrofuran / 60 - 70 °C

5.1: 41 percent / diethyl ether / 0 °C

6.1: 56 percent / p-toluenesulfonic acid monohydrate / methanol / 20 °C

With ammonium chloride; toluene-4-sulfonic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; 1.1: Addition / 2.1: Metallation / 2.2: Alkylation / 3.1: Addition / 4.1: Hydrolysis / 5.1: Addition / 6.1: Cyclization;
DOI:10.1016/S0040-4020(99)00612-2