5-hydroxy-6-phenylpiperidin-2-one

Base Information

• Chemical Name: 5-hydroxy-6-phenylpiperidin-2-one
• CAS No.: 160254-40-0
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 160254-40-0.mol

Synonyms:

Chemical Property of 5-hydroxy-6-phenylpiperidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-6-phenylpiperidin-2-one

There total 5 articles about 5-hydroxy-6-phenylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(azido(phenyl)methyl)dihydrofuran-2(3H)-one → 5-hydroxy-6-phenylpiperidin-2-one (160254-40-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; at 20 ℃; for 4h;

DOI:10.1039/c2ob06644k

Reference yield:

dihydro-5-(hydroxy(phenyl)methyl)furan-2(3H)-one → 5-hydroxy-6-phenylpiperidin-2-one (160254-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen; potassium carbonate / methanol / 4 h / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c2ob06644k

Reference yield:

C12H14O5S → 5-hydroxy-6-phenylpiperidin-2-one (160254-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen; potassium carbonate / methanol / 4 h / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c2ob06644k

upstream raw materials:

rendement diastéréoisomèrique

benzaldehyde

Downstream raw materials:

N-trifluoroacetyl-(2S,3R)-3-acetoxy-2-phenylpiperidine

C₁₃H₁₄F₃NO₂