(7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester

Base Information

• Chemical Name: (7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester
• CAS No.: 393841-43-5
• Molecular Formula: C₁₉H₂₆N₂O₉
• Molecular Weight: 426.423
• Mol file: 393841-43-5.mol

Synonyms:

Chemical Property of (7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester

There total 1 articles about (7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3,6-dioxa-1,8-diaminooctane (929-59-9,892154-56-2) + 1,2,3-tris(methoxycarbonylmethoxy)benzene (209909-16-0) → (7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester (393841-43-5) + (2-{[2-(2-{2-[2-(2,3-bis-methoxycarbonylmethoxy-phenoxy)-acetylamino]-ethoxy}-ethoxy)-ethylcarbamoyl]-methoxy}-6-methoxycarbonylmethoxy-phenoxy)-acetic acid methyl ester

Guidance literature:

In methanol; at 20 ℃; for 168h;

DOI:10.1016/j.tet.2004.05.012

Reference yield:

(7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester (393841-43-5) → (17-benzoyl-4-{2-[3-(ethoxy-dimethyl-silanyl)-propoxy]-ethoxy}-6,7,9,10,12,13,16,17,18,19-decahydro-15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-8-yl)-phenyl-methanone

Guidance literature:

Multi-step reaction with 4 steps

1.1: BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

1.2: 88 percent / HCl / H₂O / 2 h / 70 °C

2.1: 82 percent / K₂CO₃ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

3.1: 71 percent / NaH / tetrahydrofuran / 6 h / Heating

4.1: H₂PtCl₆ / CH₂Cl₂; propan-2-ol / 4 h / Heating

4.2: 35 percent / Et₃N / diethyl ether / 2 h / 20 °C

With dimethylsulfide borane complex; sodium hydride; potassium carbonate; dihydrogen hexachloroplatinate; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;

DOI:10.1016/j.tet.2004.05.012

Reference yield:

(7,18-dioxo-7,8,9,10,12,13,16,17,18,19-decahydro-6H,15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-1-yloxy)-acetic acid methyl ester (393841-43-5) → [17-benzoyl-4-(2-hydroxy-ethoxy)-6,7,9,10,12,13,16,17,18,19-decahydro-15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-8-yl]-phenyl-methanone (740809-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

1.2: 88 percent / HCl / H₂O / 2 h / 70 °C

2.1: 82 percent / K₂CO₃ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

With dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.tet.2004.05.012

upstream raw materials:

3,6-dioxa-1,8-diaminooctane

1,2,3-tris(methoxycarbonylmethoxy)benzene

Downstream raw materials:

[17-benzoyl-4-(2-hydroxy-ethoxy)-6,7,9,10,12,13,16,17,18,19-decahydro-15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-8-yl]-phenyl-methanone

[4-(2-allyloxy-ethoxy)-17-benzoyl-6,7,9,10,12,13,16,17,18,19-decahydro-15H-5,11,14,20-tetraoxa-8,17-diaza-benzocyclooctadecen-8-yl]-phenyl-methanone