(1R,2S,8aR)-1,2-dihydroxyindolizidine

Base Information

Chemical Name:(1R,2S,8aR)-1,2-dihydroxyindolizidine
CAS No.:952057-14-6
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,8aR)-1,2-dihydroxyindolizidine

Chemical Property:

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Technology Process of (1R,2S,8aR)-1,2-dihydroxyindolizidine

There total 6 articles about (1R,2S,8aR)-1,2-dihydroxyindolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 119904-07-3
(1R,2R,8aR)-1,2-(isopropylidenedioxy)indolizidine

: 952057-14-6,125279-72-3
(1R,2S,8aR)-1,2-dihydroxyindolizidine

Guidance literature:: With hydrogenchloride; at 80 ℃; for 16h;
DOI:10.1021/jo00272a025

Reference yield:

: 119795-70-9
(1R,2R,8aR)-1,2-(isopropylidenedioxy)-1,5,6,8a-tetrahydro-3(2H)-indolizinone

: 952057-14-6,125279-72-3
(1R,2S,8aR)-1,2-dihydroxyindolizidine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

2: 78 percent / LiAlH₄ / diethyl ether / 3 h / Heating

3: 72 percent / 2 M HCl / 16 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In diethyl ether; ethyl acetate;
DOI:10.1021/jo00272a025

Reference yield:

: 119795-67-4
(2R,3R)-4-hydroxy-2,3-(isopropylidenedioxy)-N-<(Z)-4-(trimethylsilyl)-3-butenyl>butanamide

: 952057-14-6,125279-72-3
(1R,2S,8aR)-1,2-dihydroxyindolizidine

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / triethylamine, SO₃*pyridine / dimethylsulfoxide / 2 h / Ambient temperature

2: 95 percent / 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 0.25 h / -20 °C

3: 72 percent / BF₃*Et₂O / CH₂Cl₂ / 4 h / Ambient temperature

4: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

5: 78 percent / LiAlH₄ / diethyl ether / 3 h / Heating

6: 72 percent / 2 M HCl / 16 h / 80 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; pyridine-SO₃ complex; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jo00272a025