((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester

Base Information

• Chemical Name: ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester
• CAS No.: 66126-73-6
• Molecular Formula: C₄₆H₃₉N₂O₈P
• Molecular Weight: 778.798
• Mol file: 66126-73-6.mol

Synonyms:

Chemical Property of ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester

There total 1 articles about ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ⁵-phosphanylidene)-acetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ5-phosphanylidene)-acetic acid benzhydryl ester (66126-73-6)

Guidance literature:

Ester 14, NaOH (S.4948);

DOI:10.1016/S0040-4039(01)86758-7

Reference yield:

((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ5-phosphanylidene)-acetic acid benzhydryl ester (66126-73-6) → (1S)-7-[benzhydryloxycarbonyl-(triphenyl-λ5-phosphanylidene)-methyl]-3,8-dioxo-(1rH,6cH)-5-oxa-2,7-diaza-bicyclo[4.2.0]octane-2-carboxylic acid benzyl ester (66126-75-8)

Guidance literature:

With N,N-dimethyl acetamide; In acetic anhydride; toluene; at 105 ℃; for 16h;

DOI:10.1016/S0040-4039(01)86758-7

Reference yield:

acetic anhydride (108-24-7) + ((2R)-3c-benzyloxycarbonylamino-2r-carboxymethoxy-4-oxo-azetidin-1-yl)-(triphenyl-λ5-phosphanylidene)-acetic acid benzhydryl ester (66126-73-6) → (6R)-3-acetoxy-7t-benzyloxycarbonylamino-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (66126-74-7)

Guidance literature:

With N,N-dimethyl acetamide; In toluene; at 105 ℃; for 16h;

DOI:10.1016/S0040-4039(01)86758-7

Downstream raw materials:

(6R)-3-acetoxy-7t-benzyloxycarbonylamino-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

(1S)-7-[benzhydryloxycarbonyl-(triphenyl-λ⁵-phosphanylidene)-methyl]-3,8-dioxo-(1rH,6cH)-5-oxa-2,7-diaza-bicyclo[4.2.0]octane-2-carboxylic acid benzyl ester

(6R)-7t-amino-3-chloro-7c-methoxy-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(6R)-7t-benzyloxycarbonylamino-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester