N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide

Base Information

• Chemical Name: N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide
• CAS No.: 1333126-83-2
• Molecular Formula: C₂₅H₂₇ClN₆O₃
• Molecular Weight: 494.981
• Mol file: 1333126-83-2.mol

Synonyms:

Chemical Property of N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide

There total 12 articles about N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Aminosalicylic acid (65-49-6) → N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide (1333126-83-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 24 h

2.1: potassium carbonate / 1 h / 110 °C

3.1: hydrogenchloride / ethanol; water / 2 h

4.1: zinc; sodium hydroxide / water / 4 h / 60 °C

4.2: pH 4 - 5

5.1: sodium hydroxide; water / ethanol / 10 h / 100 °C / Sealed ampoule

5.2: pH 8 - 9

6.1: 1 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

8.1: sodium hydroxide; ethanol / 1 h

9.1: hydrogenchloride / 48.5 h / 5 °C / Cooling with ice

With hydrogenchloride; ethanol; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) → N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide (1333126-83-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 4 h

1.2: 15 h

2.1: hydrogenchloride; tin(ll) chloride / ethyl acetate; water / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

4.1: sodium hydroxide; ethanol / 1 h

5.1: hydrogenchloride / 48.5 h / 5 °C / Cooling with ice

With hydrogenchloride; thionyl chloride; ethanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

N-(5-chloropyridine-2-yl)-2-nitrobenzamide (280771-60-0) → N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonyl-amino]benzamide (1333126-83-2)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; tin(ll) chloride / ethyl acetate; water / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

3: sodium hydroxide; ethanol / 1 h

4: hydrogenchloride / 48.5 h / 5 °C / Cooling with ice

With hydrogenchloride; ethanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

upstream raw materials:

4-Aminosalicylic acid

ortho-nitrobenzoic acid

N-(5-chloropyridine-2-yl)-2-nitrobenzamide

N-(5-chloro-2-pyridinyl)(2-amino)phenylcarboxamide