(R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate

Base Information

• Chemical Name: (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate
• CAS No.: 1310744-91-2
• Molecular Formula: C₃₀H₃₁N₃O₁₀S
• Molecular Weight: 625.656
• Mol file: 1310744-91-2.mol

Synonyms:

Chemical Property of (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate

There total 7 articles about (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(R,Z)-dimethyl 2-(3-((4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenylamino)methyl)benzamido)pentanedioate (1243277-47-5) + succinic acid monomethylester chloride (1490-25-1) → (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate (1310744-91-2)

Guidance literature:

With triethylamine; at 0 - 20 ℃; for 24h;

DOI:10.1021/jm2002525

Reference yield:

(R)-dimethyl 2-(3-formylbenzamido)pentanedioate (1243277-30-6) → (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate (1310744-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 1 h / 65 °C

1.2: 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / 24 h / 0 - 20 °C

With acetic acid; triethylamine; In methanol;

DOI:10.1021/jm2002525

Reference yield:

(5Z)-5-(4-aminobenzylidene)-1,3-thiazolidine-2,4-dione (103754-57-0) → (R,Z)-dimethyl 2-(3-((N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-methoxy-4-oxobutanamido)methyl)benzamido)pentanedioate (1310744-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 1 h / 65 °C

1.2: 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / 24 h / 0 - 20 °C

With acetic acid; triethylamine; In methanol;

DOI:10.1021/jm2002525

upstream raw materials:

(R,Z)-dimethyl 2-(3-((4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenylamino)methyl)benzamido)pentanedioate

succinic acid monomethylester chloride

(R)-dimethyl 2-(3-formylbenzamido)pentanedioate

(5Z)-5-(4-aminobenzylidene)-1,3-thiazolidine-2,4-dione

Downstream raw materials:

(R,Z)-2-(3-((3-carboxy-N-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioic acid