6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

Base Information

Chemical Name:6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline
CAS No.:1306598-86-6
Molecular Formula:C₂₂H₁₅FN₄
Molecular Weight:354.386
Hs Code.:

Synonyms:

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Chemical Property of 6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

Chemical Property:

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Technology Process of 6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

There total 8 articles about 6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1306598-78-6
6-bromo-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

: 1765-93-1
4-fluoroboronic acid

: 1306598-86-6
6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; tert-butylamine; In water; isopropyl alcohol; at 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 274-76-0
imidazo[1,2-a]pyridine

: 1306598-86-6
6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 0.33 h / 100 °C / Microwave irradiation; Neat (no solvent)

2.1: bromine / diethyl ether; dichloromethane / 0.5 h / 0 - 20 °C

3.1: triethylamine / acetonitrile / 12 h / Reflux

4.1: trifluoroacetic acid / acetonitrile / 5 h / 85 °C

4.2: pH Ca_. 8

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; tert-butylamine / water; isopropyl alcohol / 6 h / 100 °C / Inert atmosphere

With aluminum (III) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; tert-butylamine; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; water; isopropyl alcohol; acetonitrile; 1.1: Friedel-Crafts acylation / 5.1: Suzuki coupling;

Reference yield:

: 954239-15-7
tert-butyl (2-amino-4-bromophenyl)carbamate

: 1306598-86-6
6-(4-fluorophenyl)-3-(imidazo[1,2-a]pyridin-3-yl)-2-methylquinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 12 h / Reflux

2.1: trifluoroacetic acid / acetonitrile / 5 h / 85 °C

2.2: pH Ca_. 8

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; tert-butylamine / water; isopropyl alcohol / 6 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; tert-butylamine; triethylamine; trifluoroacetic acid; In water; isopropyl alcohol; acetonitrile; 3.1: Suzuki coupling;