C₁₆H₁₀F₄N₆

Base Information

• Chemical Name: C₁₆H₁₀F₄N₆
• CAS No.: 1344669-73-3
• Molecular Formula: C₁₆H₁₀F₄N₆
• Molecular Weight: 362.289
• Mol file: 1344669-73-3.mol

Synonyms:

Chemical Property of C₁₆H₁₀F₄N₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₀F₄N₆

There total 11 articles about C₁₆H₁₀F₄N₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

→ C16H10F4N6 (1344669-73-3)

Guidance literature:

With hydrazine; In ethanol; at 20 - 60 ℃; for 96h;

In dichloromethane; at 20 ℃;

With trichlorophosphate; In dichloromethane; toluene; at 65 ℃; for 0.5h; Sealed tube;

Reference yield:

ethyl 2-(pyridazin-3-yl)acetate (1260885-52-6) → C16H10F4N6 (1344669-73-3)

Guidance literature:

Multi-step reaction with 10 steps

1: sodium nitrite / water; acetic acid / 0 - 20 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 2585.81 Torr

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

4: trichlorophosphate / Heating

5: lithium hydroxide monohydrate / tetrahydrofuran; water

6: oxalyl dichloride; triethylamine / dichloromethane; N,N-dimethyl-formamide

7: ammonia / 1,4-dioxane

8: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C

9: hydrazine hydrate / methanol / 20 °C

10: 20 °C

With hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; ammonia; hydrogen; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.08.071

Reference yield:

C8H9N3O4 → C16H10F4N6 (1344669-73-3)

Guidance literature:

Multi-step reaction with 9 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 2585.81 Torr

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane

3: trichlorophosphate / Heating

4: lithium hydroxide monohydrate / tetrahydrofuran; water

5: oxalyl dichloride; triethylamine / dichloromethane; N,N-dimethyl-formamide

6: ammonia / 1,4-dioxane

7: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 0 - 20 °C

8: hydrazine hydrate / methanol / 20 °C

9: 20 °C

With hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; ammonia; hydrogen; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.08.071

upstream raw materials:

ethyl 2-(pyridazin-3-yl)acetate

C₈H₁₁N₃O₂

C₁₆H₁₄FN₃O₂

7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carbonitrile