ethyl 2-aMino-2-((1R,3r,5S)-6,6-difluorobicyclo[3.1.0]hexan-3-yl)acetate

Base Information

• Chemical Name: ethyl 2-aMino-2-((1R,3r,5S)-6,6-difluorobicyclo[3.1.0]hexan-3-yl)acetate
• CAS No.: 1307304-69-3
• Molecular Formula: C₁₀H₁₅F₂NO₂
• Molecular Weight: 219.231
• Mol file: 1307304-69-3.mol

Synonyms:

Chemical Property of ethyl 2-aMino-2-((1R,3r,5S)-6,6-difluorobicyclo[3.1.0]hexan-3-yl)acetate

Chemical Property:

• Boiling Point: 252.7±15.0 °C(Predicted)
• PKA: 7.66±0.50(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-aMino-2-((1R,3r,5S)-6,6-difluorobicyclo[3.1.0]hexan-3-yl)acetate

There total 6 articles about ethyl 2-aMino-2-((1R,3r,5S)-6,6-difluorobicyclo[3.1.0]hexan-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H23F2NO2 (1307304-68-2) → C10H15F2NO2 (1307304-69-3)

Guidance literature:

C₂₃H₂₃F₂NO₂; With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

cyclopent-3-enol (14320-38-8) → C10H15F2NO2 (1307304-69-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: sodium fluoride / 100 °C / Neat (no solvent)

3.1: potassium hydroxide; water / methanol / 20 °C

4.1: pyridine / dichloromethane / 20 °C

5.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 5 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

6.1: hydrogenchloride / water; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; water; sodium fluoride; triethylamine; potassium hydroxide; lithium hexamethyldisilazane; pyridine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

C13H12F2O2 (1307886-65-2) → C10H15F2NO2 (1307304-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide; water / methanol / 20 °C

2: pyridine / dichloromethane / 20 °C

3: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 5 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4: hydrogenchloride / water; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; water; potassium hydroxide; lithium hexamethyldisilazane; pyridine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

upstream raw materials:

cyclopent-3-enol

C₁₃H₁₂F₂O₂

C₆H₈F₂O

C₁₃H₁₄F₂O₃S

Refernces

• 1、 -. "HEPATITIS C VIRUS INHIBITORS". . . Retrieved 2012/12/13.