Technology Process of 8-ethyl-1,2-dihydro-6,7-dimethoxy-2-methyl-3-(4-methylphenylmethyl)naphthalene
There total 9 articles about 8-ethyl-1,2-dihydro-6,7-dimethoxy-2-methyl-3-(4-methylphenylmethyl)naphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: polyphosphoric ester / dichloromethane / 5 h / Reflux
2: potassium hydroxide / ethanol; water / 20 °C
3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 1551.49 Torr / Autoclave
4: sodium tetrahydroborate / ethanol / 2 h / Reflux
5: hydrogenchloride / water / 2 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium hydroxide;
In
ethanol; dichloromethane; water; ethyl acetate;
1: Friedel-Crafts acylation / 2: Aldol condensation;
DOI:10.1016/j.tetlet.2011.11.065
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium hydroxide / ethanol; water / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 1551.49 Torr / Autoclave
3: sodium tetrahydroborate / ethanol / 2 h / Reflux
4: hydrogenchloride / water / 2 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium hydroxide;
In
ethanol; water; ethyl acetate;
1: Aldol condensation;
DOI:10.1016/j.tetlet.2011.11.065
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / Reflux
1.2: 12 h / 0 - 20 °C
2.1: potassium hydroxide / ethanol; water / 8 h / Reflux
2.2: Cooling with ice
3.1: palladium 10% on activated carbon; hydrogen; acetic acid / 8 h / 60 °C / 3102.97 Torr / Autoclave
4.1: polyphosphoric ester / dichloromethane / 5 h / Reflux
5.1: potassium hydroxide / ethanol; water / 20 °C
6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 1551.49 Torr / Autoclave
7.1: sodium tetrahydroborate / ethanol / 2 h / Reflux
8.1: hydrogenchloride / water / 2 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; ethyl bromide; palladium 10% on activated carbon; hydrogen; iodine; magnesium; acetic acid; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
4.1: Friedel-Crafts acylation / 5.1: Aldol condensation;
DOI:10.1016/j.tetlet.2011.11.065
