(S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Base Information

• Chemical Name: (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride
• CAS No.: 79784-49-9
• Molecular Formula: C₂₉H₃₄N₂O₆*ClH
• Molecular Weight: 543.06
• Mol file: 79784-49-9.mol

Synonyms:

Chemical Property of (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

There total 6 articles about (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril (79784-54-6) → (R)(+)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride (74245-69-5,79784-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / dimethylformamide / 9.5 h / 60 - 65 °C

2: 3.5N KOH / methanol / 1 h / Ambient temperature

3: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

With piperidine; hydrogenchloride; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.29.2157

Reference yield:

5-hydroxy-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril (79784-54-6) → (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride (79784-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 21 percent / piperidine / dimethylformamide / 9.5 h / 60 - 65 °C

2: 83 percent / 3.5N KOH / methanol / 1 h / Ambient temperature

3: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

With piperidine; hydrogenchloride; potassium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.29.2157

Reference yield:

(R)(-)-5-(3-chloro-2-hydroxypropoxy)-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril (79784-48-8,79815-04-6) → (S)(-)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride (79784-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 3.5N KOH / methanol / 1 h / Ambient temperature

2: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

With hydrogenchloride; potassium hydroxide; In methanol;

DOI:10.1248/cpb.29.2157

upstream raw materials:

N-benzyl-2-(3,4-dimethoxyphenyl)ethylamine

(R)-5-(2,3-epoxypropoxy)-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril

5-hydroxy-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril

(S)(-)-5-(3-chloro-2-hydroxypropoxy)-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril

Downstream raw materials:

(S)(-)-8-acetonyloxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

(S)(-)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

(R)(+)-8-acetonyloxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril

(R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate