C₄₃H₅₇FN₄O₇

Base Information

Chemical Name:C₄₃H₅₇FN₄O₇
CAS No.:1365993-80-1
Molecular Formula:C₄₃H₅₇FN₄O₇
Molecular Weight:760.947
Hs Code.:

C<sub>43</sub>H<sub>57</sub>FN<sub>4</sub>O<sub>7</sub>

Synonyms:

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Chemical Property of C₄₃H₅₇FN₄O₇

Chemical Property:

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Technology Process of C₄₃H₅₇FN₄O₇

There total 12 articles about C₄₃H₅₇FN₄O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[3-(4-fluorophenyl)acryloyl]-(S)-4-phenyl-oxazolidin-2-one

: 1365993-80-1
C₄₃H₅₇FN₄O₇

Guidance literature:: Multi-step reaction with 10 steps

1.1: copper(I) bromide dimethylsulfide complex; methylmagnesium bromide / tetrahydrofuran; dimethylsulfide; dibutyl ether / 0 - 20 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 0 °C / Inert atmosphere

3.1: sodium azide / dimethyl sulfoxide / 45 h / 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

6.1: caesium carbonate / methanol; water / pH 8 / Inert atmosphere

6.2: 1 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C / Inert atmosphere

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

9.1: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; copper(I) bromide dimethylsulfide complex; di-n-butylboryl trifluoromethanesulfonate; palladium 10% on activated carbon; methylmagnesium bromide; water; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dimethylsulfide; dichloromethane; dibutyl ether; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm2007062

Reference yield:

: C₂₂H₂₆FNO₄

: 1365993-80-1
C₄₃H₅₇FN₄O₇

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; HATU; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm2007062

Reference yield:

: C₁₉H₁₇FN₄O₃

: 1365993-80-1
C₄₃H₅₇FN₄O₇

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

3.1: caesium carbonate / methanol; water / pH 8 / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2007062