3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

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Chemical Name:3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
CAS No.:1049815-87-3
Molecular Formula:C₃₆H₃₆Cl₂N₆O₂S
Molecular Weight:687.693
Hs Code.:

3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

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Chemical Property of 3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

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Technology Process of 3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

There total 4 articles about 3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₄₄Cl₂N₆O₄S

: 1049815-87-3
3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2012.12.014

Reference yield:

: 144693-65-2
4-ethynylbenzoic acid sodium salt

: 1049815-87-3
3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2012.12.014

Reference yield:

: 120157-95-1
(4-chlorobenzyl)carbamic acid tert-butyl ester

: 1049815-87-3
3-(4-Chloro-3-{[4-([(4-chlorophenyl)methyl]aminocarbonyl)phenyl]ethynyl]phenyl)-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2012.12.014