methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

Base Information

Chemical Name:methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate
CAS No.:131080-24-5
Molecular Formula:C₂₆H₃₀N₂O₅S
Molecular Weight:482.601
Hs Code.:

methyl 2-<2-<N-(phenylsulfonyl)indolyl>>-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

Synonyms:

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Chemical Property of methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

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Technology Process of methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

There total 5 articles about methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37675-20-0
(R)-3-hydroxymethyl piperidine

: 131080-24-5,131080-25-6
methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / triethylamine / ethanol / 12 h / Heating

2: 99 percent / standard manner

3: 80 percent / LiBr / acetone / 18 h / Heating

4: 1.) Mg, 1,2-dibromoethane / 1.) THF, 3 h, reflux, 2.)THF, 0 deg C, 30 min

With magnesium; ethylene dibromide; triethylamine; lithium bromide; In ethanol; acetone;
DOI:10.1021/jo00003a045

Reference yield:

: 131080-21-2
(R)-(+)-N-allyl-3-piperidinomethanol

: 131080-24-5,131080-25-6
methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / standard manner

2: 80 percent / LiBr / acetone / 18 h / Heating

3: 1.) Mg, 1,2-dibromoethane / 1.) THF, 3 h, reflux, 2.)THF, 0 deg C, 30 min

With magnesium; ethylene dibromide; lithium bromide; In acetone;
DOI:10.1021/jo00003a045

Reference yield:

: 131080-22-3
(R)-(+)-N-allyl-3-piperidinylmethanol methanesulfonate

: 131080-24-5,131080-25-6
methyl 2-<2->-2-hydroxy-3-<3-(N-allylpiperidinyl)>propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / LiBr / acetone / 18 h / Heating

2: 1.) Mg, 1,2-dibromoethane / 1.) THF, 3 h, reflux, 2.)THF, 0 deg C, 30 min

With magnesium; ethylene dibromide; lithium bromide; In acetone;
DOI:10.1021/jo00003a045