4-chlorobenzyl butanoate

Base Information

• Chemical Name: 4-chlorobenzyl butanoate
• CAS No.: 16932-26-6
• Molecular Formula: C11H13 Cl O2
• Molecular Weight: 212.6727
• Mol file: 16932-26-6.mol

Synonyms:Butyricacid, p-chlorobenzyl ester (8CI); Benzyl alcohol, p-chloro-, butyrate;4-Chlorobenzyl butyrate; NSC 404754

Chemical Property of 4-chlorobenzyl butanoate

Chemical Property:

• Vapor Pressure: 0.00579mmHg at 25°C
• Boiling Point: 273.3°C at 760 mmHg
• Flash Point: 125.6°C
• Density: 1.136g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chlorobenzyl butanoate

There total 3 articles about 4-chlorobenzyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-chlorobenzaldehyde (104-88-1) + butyric acid (107-92-6) → 4-chlorobenzyl butyrate (16932-26-6)

Guidance literature:

With rhodium(III) chloride; carbon monoxide; water; In toluene; at 160 ℃; under 22801.5 Torr; Autoclave;

DOI:10.1002/ejoc.202000438

Reference yield: 69.0%

butyraldehyde (123-72-8) + para-Chlorobenzyl alcohol (873-76-7) → 4-chlorobenzyl butyrate (16932-26-6)

Guidance literature:

With Phenazin; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 60 ℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.7b01617

Reference yield:

→ 4-chlorobenzyl butyrate (16932-26-6)

Guidance literature:

p-Cl-C6H4-CH2-OH + R-COOH.;

upstream raw materials:

butyraldehyde

para-Chlorobenzyl alcohol

4-chlorobenzaldehyde

butyric acid

Refernces

• 1、 Chun, Supill,Chung, Young Keun. "Transition-Metal-Free Poly(thiazolium) Iodide/1,8-Diazabicyclo[5.4.0]undec-7-ene/Phenazine-Catalyzed Esterification of Aldehydes with Alcohols". supporting information. p. 3787 - 3790. Retrieved 2017/07/26.