6-(difluoromethyl)pyridin-2-amine

Base Information

• Chemical Name: 6-(difluoromethyl)pyridin-2-amine
• CAS No.: 1315611-68-7
• Molecular Formula: C₆H₆F₂N₂
• Molecular Weight: 144.124
• Hs Code.: 2933399990

Synonyms:

Chemical Property of 6-(difluoromethyl)pyridin-2-amine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-6-(difluoromethyl)pyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(difluoromethyl)pyridin-2-amine

There total 2 articles about 6-(difluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-(difluoromethyl)pyridine (872365-91-8) → 6-(difluoromethyl)pyridin-2-amine (1315611-68-7)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; potassium carbonate; N,N`-dimethylethylenediamine; In ethylene glycol; for 22h; Reflux;

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → 6-(difluoromethyl)pyridin-2-amine (1315611-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / Cooling with ice

2: copper(I) oxide; N,N`-dimethylethylenediamine; potassium carbonate; ammonium hydroxide / ethylene glycol / 22 h / Reflux

With copper(I) oxide; ammonium hydroxide; diethylamino-sulfur trifluoride; potassium carbonate; N,N`-dimethylethylenediamine; In dichloromethane; ethylene glycol;

Reference yield:

6-(difluoromethyl)pyridin-2-amine (1315611-68-7) + C12H9FN2O3 → C17H12F2N4O2

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.09.001

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

2-bromo-6-(difluoromethyl)pyridine

Downstream raw materials:

C₁₇H₁₁ClF₂N₄O₂

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