N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride

Base Information

• Chemical Name: N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride
• CAS No.: 1807-12-1
• Molecular Formula: C₂₃H₃₀N₂O*ClH
• Molecular Weight: 386.965

Synonyms:

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Chemical Property of N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride

There total 6 articles about N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride (1807-12-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) p-toluene sulphonic acid; 2.) molecular sieve 4A / toluene / 1.) reflux 7 h; 2.) reflux overnight

2: sodium borohydride / methanol / 2 h / Heating

3: toluene / Heating

4: toluene / Heating

5: 50percent acetic acid / 6 h / Heating

6: 1.) Na₂CO₃, few cryst. KI; 2.) HCl / 24 h

With hydrogenchloride; sodium tetrahydroborate; 4 A molecular sieve; sodium carbonate; toluene-4-sulfonic acid; acetic acid; In methanol; toluene;

DOI:10.1111/j.2042-7158.1988.tb05318.x

Reference yield:

p-toluidine (106-49-0,12221-03-3) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride (1807-12-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) p-toluene sulphonic acid; 2.) molecular sieve 4A / toluene / 1.) reflux 7 h; 2.) reflux overnight

2: sodium borohydride / methanol / 2 h / Heating

3: toluene / Heating

4: toluene / Heating

5: 50percent acetic acid / 6 h / Heating

6: 1.) Na₂CO₃, few cryst. KI; 2.) HCl / 24 h

With hydrogenchloride; sodium tetrahydroborate; 4 A molecular sieve; sodium carbonate; toluene-4-sulfonic acid; acetic acid; In methanol; toluene;

DOI:10.1111/j.2042-7158.1988.tb05318.x

Reference yield:

N-(1-methylpiperidylidene-4)-p-toluidine (99918-50-0) → N-(4-Methylphenyl)-N-<1-(2-phenylethyl)-4-piperidyl>propanamide Hydrochloride (1807-12-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium borohydride / methanol / 2 h / Heating

2: toluene / Heating

3: toluene / Heating

4: 50percent acetic acid / 6 h / Heating

5: 1.) Na₂CO₃, few cryst. KI; 2.) HCl / 24 h

With hydrogenchloride; sodium tetrahydroborate; sodium carbonate; acetic acid; In methanol; toluene;

DOI:10.1111/j.2042-7158.1988.tb05318.x

upstream raw materials:

N-piperidin-4-yl-N-p-tolyl-propionamide

1-phenyl-2-bromoethane

1-Methyl-4-piperidone

N-(1-methylpiperidylidene-4)-p-toluidine