4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester

Base Information

• Chemical Name: 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester
• CAS No.: 113019-24-2
• Molecular Formula: C₅₁H₆₃O₁₃P
• Molecular Weight: 915.027

Synonyms:

Chemical Property of 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester

There total 5 articles about 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C48H59Cl2O10P → 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester (113019-24-2,113084-87-0)

Guidance literature:

Multi-step reaction with 4 steps

2: 74 percent / t-BuO₂H

3: 85 percent / DDQ / CH₂Cl₂

4: DCC/DMAP / CH₂Cl₂

With tert.-butylhydroperoxide; dmap; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1016/S0040-4039(00)96160-4

Reference yield:

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1R,2S,3R,4R,5S,6S)-2,5-bis-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-3,4-bis-(4-methoxy-benzyloxy)-cyclohexyl ester → 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester (113019-24-2,113084-87-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / t-BuO₂H

2: 85 percent / DDQ / CH₂Cl₂

3: DCC/DMAP / CH₂Cl₂

With tert.-butylhydroperoxide; dmap; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1016/S0040-4039(00)96160-4

Reference yield:

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2R,3S,4S,5R,6R)-2,5-bis-benzyloxy-6-(bis-benzyloxy-phosphoryloxy)-3,4-bis-(4-methoxy-benzyloxy)-cyclohexyl ester (111331-55-6,111408-71-0) → 4-Oxo-pentanoic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-3-(bis-benzyloxy-phosphoryloxy)-6-hydroxy-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester (113019-24-2,113084-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / DDQ / CH₂Cl₂

2: DCC/DMAP / CH₂Cl₂

With dmap; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1016/S0040-4039(00)96160-4

upstream raw materials:

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2R,3S,4S,5R,6R)-2,5-bis-benzyloxy-6-(bis-benzyloxy-phosphoryloxy)-3,4-dihydroxy-cyclohexyl ester

levulinic acid

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2R,3S,4S,5R,6R)-2,5-bis-benzyloxy-6-(bis-benzyloxy-phosphoryloxy)-3,4-bis-(4-methoxy-benzyloxy)-cyclohexyl ester

benzyl alcohol

Downstream raw materials:

4-Oxo-pentanoic acid (1R,2R,3R,4S,5S,6R)-2,5-bis-benzyloxy-3,6-bis-(bis-benzyloxy-phosphoryloxy)-4-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-cyclohexyl ester

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2R,3R,4S,5R,6R)-2,5-bis-benzyloxy-4,6-bis-(bis-benzyloxy-phosphoryloxy)-3-hydroxy-cyclohexyl ester

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2S,3S,4R,5R,6R)-2,5-bis-benzyloxy-3,6-bis-(bis-benzyloxy-phosphoryloxy)-4-hydroxy-cyclohexyl ester

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (1S,2S,3R,4R,5S,6R)-2,5-bis-benzyloxy-3,4,6-tris-(bis-benzyloxy-phosphoryloxy)-cyclohexyl ester

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