(6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate

Base Information

• Chemical Name: (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate
• CAS No.: 1373822-31-1
• Molecular Formula: C₂₁H₂₅ClN₅O₉P
• Molecular Weight: 557.884
• Mol file: 1373822-31-1.mol

Synonyms:

Chemical Property of (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate

There total 2 articles about (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-7-(2-(4-chlorophenoxy)ethyl)-9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium → (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate (1373822-31-1)

Guidance literature:

With trimethyl phosphite; trichlorophosphate; at 0 - 20 ℃; for 0.5h;

DOI:10.1021/jm300037x

Reference yield:

1-(2-bromoethoxy)-4-chlorobenzene (2033-76-3) + 2',3'-isopropylideneguanosine (362-76-5) → (6-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-7-ium-9(6H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]-dioxol-4-yl)methyl phosphate (1373822-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 72 h / 60 °C

2: trimethyl phosphite; trichlorophosphate / 0.5 h / 0 - 20 °C

With trimethyl phosphite; trichlorophosphate; In dimethyl sulfoxide;

DOI:10.1021/jm300037x

upstream raw materials:

1-(2-bromoethoxy)-4-chlorobenzene

2',3'-isopropylideneguanosine